McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, et al. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med. 2008;5:1590–606.
Symonds T, Roblin D, Hart K, Althof S. How does premature ejaculation impact a man’s life? J Sex Marital Ther. 2003;29:361–70.
Waldinger MD. The pathophysiology of lifelong premature ejaculation. Transl Androl Urol. 2016;5:424–33.
Waldinger MD. Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: a new hypothesis. Pharmacol Biochem Behav. 2014;121:189–94.
Gazzaley A, Rissman J, Cooney J, Rutman A, Seibert T, Clapp W, et al. Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing. Cereb Cortex. 2007;17(Suppl 1):i125–i135.
Snyder AC, Yu BM, Smith MA. A stable population code for attention in prefrontal cortex leads a dynamic attention code in visual cortex. J Neurosci. 2021;41:9163–76.
Stoléru S, Fonteille V, Cornélis C, Joyal C, Moulier V. Functional neuroimaging studies of sexual arousal and orgasm in healthy men and women: a review and meta-analysis. Neurosci Biobehav Rev. 2012;36:1481–509.
Zhang B, Lu J, Xia J, Wang F, Li W, Chen F, et al. Functional insights into aberrant brain responses and integration in patients with lifelong premature ejaculation. Sci Rep. 2017;7:460.
Xu Z, Yang X, Gao M, Liu L, Sun J, Liu P, et al. Abnormal resting-state functional connectivity in the whole brain in lifelong premature ejaculation patients based on machine learning approach. Front Neurosci. 2019;13:448.
Gao M, Feng N, Liu X, Sun J, Hou G, Zhang L, et al. Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study. Brain Imaging Behav. 2021;15:1412–9.
Faraone SV, Ward CL, Boucher M, Elbekai R, Brunner E. Role of serotonin in psychiatric and somatic comorbidities of attention-deficit/hyperactivity disorder: a systematic literature review. Neurosci Biobehav Rev. 2025;176:106275.
Giuliano F, Clément P. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol. 2006;50:454–66.
Singh H, Singh J. Human eye tracking and related issues: a review. Int J Sci Res Publ. 2012;2:1–9.
Li Q, Pan Y. Mobile eye-tracking and neuroimaging technologies reveal teaching and learning on the move: bibliometric mapping and content analysis. Psychoradiology. 2025;5:kkaf013.
Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An update of the international society of sexual Medicine’s guidelines for the diagnosis and treatment of Premature Ejaculation (PE). Sex Med. 2014;2:60–90.
Huang YP, Chen B, Ping P, Wang HX, Hu K, Zhang T, et al. The premature ejaculation diagnostic tool (PEDT): linguistic validity of the Chinese version. J Sex Med. 2014;11:2232–8.
Rosen RC, Cappelleri J, Smith M, Lipsky J, Pena B. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11:319–26.
Zhu J. Nanzi boqigongneng zhang’ai zhenzhi zhinan [Guidelines for diagnosis and treatment of male erectile dysfunction]. Zhongguo Nan Ke Xue Za Zhi[Chinese Journal of Andrology]. 2004;18:68–72.
Li Y, Li X, Wang Z, Chen X, Sescousse G, Santtila P, et al. Altered reward processing in patients with lifelong premature ejaculation. Sci Rep. 2023;13:17539.
Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol. 2007;52:565–73.
Zhong Q, Wang C, Zhu D, Pang KH, Colonnello E, Sansone A, et al. The severity classification of lifelong premature ejaculation based on the premature ejaculation diagnostic tool. Andrology. 2025:1–8. https://doi.org/10.1111/andr.70124
Zung WW. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63–70.
Zung WW. A rating instrument for anxiety disorders. Psychosomatics. 1971;12:371–9.
Rowland DL, Patrick DL, Rothman M, Gagnon DD. The psychological burden of premature ejaculation. J Urol. 2007;177:1065–70.
Baddeley RJ, Tatler BW. High frequency edges (but not contrast) predict where we fixate: a Bayesian system identification analysis. Vision Res. 2006;46:2824–33.
Parkhurst D, Law K, Niebur E. Modeling the role of salience in the allocation of overt visual attention. Vision Res. 2002;42:107–23.
Hooge ITC, Holleman GA, Haukes NC, Hessels RS. Gaze tracking accuracy in humans: one eye is sometimes better than two. Behav Res Methods. 2019;51:2712–21.
Lykins AD, Meana M, Strauss GP. Sex differences in visual attention to erotic and non-erotic stimuli. Arch Sex Behav. 2007;37:219–28.
Hall C, Hogue T, Guo K. Differential gaze behavior towards sexually preferred and non-preferred human figures. J Sex Res. 2011;48:461–9.
Rupp HA, Wallen K. Sex differences in viewing sexual stimuli: an eye-tracking study in men and women. Horm Behav. 2007;51:524–33.
Fromberger P, Jordan K, von Herder J, Steinkrauss H, Nemetschek R, Stolpmann G, et al. Initial orienting towards sexually relevant stimuli: preliminary evidence from eye movement measures. Arch Sex Behav. 2012;41:919–28.
Milani S, Zhang JY, Zdaniuk B, Bogaert A, Rieger G, Brotto LA. Examining visual attention patterns among asexual and heterosexual individuals. J Sex Res. 2023;60:271–81.
Velten J, Brown NB, Peragine D, VanderLaan DP, Kingstone A, Brotto LA. Cognitive processing of sexual cues in asexual individuals and heterosexual women with desire/arousal difficulties. PloS one. 2021;16:e0251074.
Hessels RS, Kemner C, van den Boomen C, Hooge IT. The area-of-interest problem in eyetracking research: a noise-robust solution for face and sparse stimuli. Behav Res Methods. 2016;48:1694–712.
Haq AU, Li J, Memon MH, Memon MH, Khan J, Marium SM Heart disease prediction system using model of machine learning and sequential backward selection algorithm for features selection. In: Proceedings of the 2019 IEEE 5th International Conference for Convergence in Technology (I2CT); 2019; Bombay, India. Piscataway (NJ): IEEE; 2019. p. 1-4.
Hearst MA, Dumais ST, Osuna E, Platt J, Scholkopf B. Support vector machines. IEEE Intell Syst. 1998;13:18–28.
Wang M, Zhao S-W, Wu D, Zhang Y-H, Han Y-K, Zhao K, et al. Transcriptomic and neuroimaging data integration enhances machine learning classification of schizophrenia. Psychoradiology. 2024;4:kkae005.
Vehtari A, Gelman A, Gabry J. Practical bayesian model evaluation using leave-one-out cross-validation and WAIC. Stat Comput. 2017;27:1413–32.
Ojala M, Garriga GC. Permutation tests for studying classifier performance. J Mach Learn Res. 2010;11:1833–63.
Garza R, Heredia RR, Cieslicka AB. Male and female perception of physical attractiveness: an eye movement study. Evol Psychol. 2016;14:1474704916631614.
Putkinen V, Lewandowski E, Santavirta S, Nummenmaa L. Sex differences in gaze patterns while viewing dynamic and static sexual scenes. Maturitas. 2025;202:108714.
Ülkü Beşiktepe A, Medine Gıynaş A. Lifelong premature ejaculation and attention-deficit hyperactivity disorder: a controlled study. Alpha Psychiatry. 2022;23:135–9.
Yang X, Gao M, Zhang L, Liu L, Liu P, Sun J, et al. Central neural correlates during inhibitory control in lifelong premature ejaculation patients. Front Hum Neurosci. 2018;12:206.
Rajkumar RP, Kumaran AK. Depression and anxiety in men with sexual dysfunction: a retrospective study. Compr Psychiatry. 2015;60:114–8.
Mourikis I, Antoniou M, Matsouka E, Vousoura E, Tzavara C, Ekizoglou C, et al. Anxiety and depression among Greek men with primary erectile dysfunction and premature ejaculation. Ann Gen Psychiatry. 2015;14:34.
TAO L, Chao J, Yi-Feng P, Wan Z, Xiang F. Correlation between premature ejaculation and psychological disorders in 270 Chinese outpatients. Psychiatry Res. 2019;272:69–72.
Kempeneers P, Andrianne R, Bauwens S, Georis I, Pairoux JF, Blairy S. Functional and psychological characteristics of Belgian men with premature ejaculation and their partners. Arch Sex Behav. 2013;42:51–66.
Kalin NH. The critical relationship between anxiety and depression. Am J Psychiatry. 2020;177:365–7.
Lin J, Liu W, Guan J, Cui J, Shi R, Wang L, et al. Latest updates on the serotonergic system in depression and anxiety. Front Synaptic Neurosci. 2023;15:1124112.